IMMUNO RESOURCE
HLA CLASS I
Introduction
Immunoresource : Noncanonical MHC-I associated peptide database compounded by proteogenomic analysis of immunopeptidome data
ImmunoResource, a database of ncMAPs identified by a novel proteogenomic method called pXg(https://github.com/HanyangBISLab/pXg), facilitating discovery of a broader range of ncMAPs. ImmunoResource provides extensive genomic annotations, including the RNA read coverage, serving as a valuable and practical resource for immunotherapy development.
We collected hundreds of raw files from various public resources, along with their HLA types. Since our method requires paired MHC-I immunopeptidome and RNA-seq data, a select sample pool was advanced to analysis.
As a result, We successfully identified hundreds of thousands of canonical MAPs (cMAPs) and unearthed thousands of ncMAPs. We provide all these peptides for use in immunotherapy research
Reference
Choi S, Paek E. pXg: Comprehensive Identification of Noncanonical MHC-I-Associated Peptides From De Novo Peptide Sequencing Using RNA-Seq Reads. Mol Cell Proteomics. 2024 Apr;23(4):100743. doi.org/10.1016/j.mcpro.2024.100743.Epub 2024 Feb 23. PMID: 38403075; PMCID: PMC10979277.
Statistics
| Type | Total | Binder | Binder Ratio |
|---|---|---|---|
| Canonical PSMs | 371,249 | 360,662 | 0.971483 |
| Non-canonical PSMs | 7,835 | 7,371 | 0.940779 |
| Canonical Peptides | 57,295 | 53,812 | 0.939209 |
| Non-canonical Peptides | 2,156 | 1,949 | 0.903989 |